University of Minnesota - IBM
Computational Life Sciences Program

Principal Investigators
Principal Investigator:Yusuf Abul-Hajj
Department:Medicinal Chemistry
Title of Project:no title on file
 
Principal Investigator:Leonard J. Banaszak
Department:Biochemistry, Molecular Biology, and Biophysics
Title of Project:Structure-Function Studies of Lipoprotein Systems
 
Principal Investigator:Victor H. Barocas
Department:Biomedical Engineering
Title of Project:Computational Biological and Biomedical Research
 
Principal Investigator:Bridgette A. Barry
Department:Biochemistry, Molecular Biology, and Biophysics
Title of Project:In Vivo, In Vitro, and Calculated Vibrational Spectra of Plastoquinone and the Plastosemiquinone Anion Radical
 
Principal Investigator:Judith Berman
Department:Genetics, Cell Biology, and Development
Title of Project:Candida Albincans Genome Database for Use With Microarray Analysis
 
Principal Investigator:Ann Bode
Department:Hormel Institute
Title of Project:Protein-Protein Interactions in Signal Transduction Pathways
 
Principal Investigator:Mervyn de Souza
Department:Cargill
Title of Project:Metabolic Engineering of Biosynthetic Processes
 
Principal Investigator:Zigang Dong
Department:Hormel Institute
Title of Project:Protein-Protein Interactions in Signal Transduction Pathways
 
Principal Investigator:Steve Ekker
Department:Genetics, Cell Biology, and Development
Title of Project:Systematic Vertebrate Functional Genomics
 
Principal Investigator:Lynda Ellis
Department:Biotechnology Institute
Title of Project:Functional Analysis and Discovery of Microbial Genes Transforming Metallic and Organic Pollutants
 
Principal Investigator:Stanley L. Erlandsen
Department:Genetics, Cell Biology, and Development
Title of Project:Quantitation of Expression of Endothelial Cell Adhesion Molecules (CAM) In Vivo by High Resolution Field Emission SEM (FESEM) of Vascular Casts
 
Principal Investigator:David Ferguson
Department:Medicinal Chemistry
Title of Project:Simulations of DNA Hairpin Loop Structures Using Molecular Dynamics
 
Principal Investigator:Jiali Gao
Department:Chemistry
Title of Project:Molecular Modeling of Enzyme Reactions
 
Principal Investigator:William Gleason
Department:Laboratory Medicine and Pathology
Title of Project:The Use of a Small, Dedicated Linux Cluster for Bioinformatics/Proteomics: Applications in the Area of "On-the-Fly" Mass Spectral Data Interpretation
 
Principal Investigator:David Grant
Department:Pharmacology
Title of Project:Effects of Impurities Incorporated During Crystallization on the Crystal Properties of Some Therapeutic Agents
 
Principal Investigator:Alexander Grosberg
Department:Physics
Title of Project:Monte Carlo Simulations of Toy Proteins with Several Distinct Stable States
 
Principal Investigator:Ashley Haase
Department:Microbiology
Title of Project:Biomedical Genomics
 
Principal Investigator:Tom Hays
Department:Genetics, Cell Biology, and Development
Title of Project:Using Imaging Technology to Study the Function and Regulation of Cytoplasmic Dynein
 
Principal Investigator:Wei-Shou Hu
Department:Chemical Engineering and Materials Science
Title of Project:Genomics of Antibiotic Biosynthesis in Streptomyces Coelicolor
 
Principal Investigator:Vivek Kapur
Department:Computer Science and Engineering
Title of Project:Microbial Pathogenomics
 
Principal Investigator:George Karypis
Department:Computer Science and Engineering
Title of Project:Scalable Algorithms for Knowledge Discover in Scientific Data Sets
 
Principal Investigator:Yiannis Kaznessis
Department:Chemical Engineering and Materials Science
Title of Project:Development of Novel Structural Bioinformatics Algorithms
 
Principal Investigator:Arkady Khodursky
Department:Biochemistry, Molecular Biology, and Biophysics
Title of Project:Structure, Activity, and Logic of the Escherichia coli Transcriptional Networks
 
Principal Investigator:Vipin Kumar
Department:Computer Science and Engineering
Title of Project:Parallel Algorithms for High Performance, Multi-Physics, and Adaptive Mesh Simulations
 
Principal Investigator:David G. Levitt
Department:Physiology
Title of Project:Development of Software to Automate the Building of Protein Structures into X-ray Crystallographic Electron Density Maps
 
Principal Investigator:Patrick Mantyh
Department:Neuroscience
Title of Project:Bone Innervation
 
Principal Investigator:Kevin Mayo
Department:Laboratory Medicine and Pathology
Title of Project:Protein Studies: Internal Motion Dynamics and Solution Structures
 
Principal Investigator:Karin Musier-Forsyth
Department:Chemistry
Title of Project:Probing RNA-Protein Interactions via Molecular Dynamics Simulations
 
Principal Investigator:Doug Ohlendorf
Department:Biochemistry, Molecular Biology, and Biophysics
Title of Project:Structural Analysis of Macromolecules
 
Principal Investigator:Hans Othmer
Department:Mathematics
Title of Project:Mathematical Modeling of Vertebrate Limb Development
 
Principal Investigator:Yuan-Ping Pang
Department:Department of Pharmacology, Mayo Medical School
Title of Project:Development of Second-Generation Farnesyltransferase Inhibitors as Cancer Drugs
 
Principal Investigator:Jim Pankow
Department:Epidemiology
Title of Project:Genetic Epidemiology of Cardiovascular Disease and Associated Risk Factors
 
Principal Investigator:Ronald Phillips
Department:Agronomy and Plant Genetics
Title of Project:no title on file
 
Principal Investigator:Philip Portoghese
Department:Medicinal Chemistry
Title of Project:Modeling of Opioid and Chemokine Receptors with Their Ligands
 
Principal Investigator:David H. Sherman
Department:Microbiology
Title of Project:Genomics of Antibiotic Biosynthesis in Streptomyces Coelicolor
 
Principal Investigator:David D. Thomas
Department:Biochemistry, Molecular Biology, and Biophysics
Title of Project:Differences in Structural Dynamics of Muscle and Yeast Actin Accompany Differences in Functional Interactions With Myosin
 
Principal Investigator:Donald G. Truhlar
Department:Chemistry
Title of Project:Molecular Modeling of Enzyme Reactions
 
Principal Investigator:Larry Wackett
Department:Biotechnology Institute
Title of Project:Functional Analysis and Discovery of Microbial Genes Transforming Metallic and Organic Pollutants
 
Principal Investigator:Carston D. Wagner
Department:Medicinal Chemistry
Title of Project:Chemical Biology of Induce Protein Dimerization
 
Principal Investigator:George Wilcox
Department:Neuroscience
Title of Project:Axonal Propagation of Impulses in Peripheral Afferents: Model Based on Molecular Information
 
Principal Investigator:Darrin York
Department:Chemistry
Title of Project:Multi-Level Quantum Simulations of Phosphate Hydrolysis Reactions in Enzymes