UMSI 2000 Annual Report: Ian M. Armitage, Principal Investigator Previous Page  |  Table of Contents  |  Next Page

Ian M. Armitage, Principal Investigator


Structure/Function of Biomolecules Involved in Immune Suppression and Cellular Metal Homeostasis
Research Group

Brian M. Johnson, Undergraduate Student Researcher
Kyal Klawitter, Graduate Student Researcher
Khai Leon Le, Undergraduate Student Researcher
David Live, Research Associate
Melissa McCornack, Graduate Student Researcher
Ryan T. McKay, Research Associate
Beverly G. Ostrowski, Research Associate
Gulin Oz, Graduate Student Researcher
Ajay Royyuru, Thomas Watson IBM Research Laboratory, Yorktown Heights, New York
Carmen Silvers, Staff
Klaus Zangger, Research Associate


1999 UMSI Publications

99/248
 "Three-Dimensional Solution Structure of Mouse [Cd7]-Metallothionein-1 Homonuclear and Heteronuclear NMR Spectroscopy," K. Zangger, G. Oz, J.D. Otvos, and I.M. Armitage, Protein Science, 8, p. 2630 (1999).
A complete Bibliography can be found on the Internet at:
www.msi.umn.edu/cgi-bin/reports/searchv2.html

This research group's activities revolve around the use of Nuclear Magnetic Resonance (NMR) methods to elucidate the solution tertiary structure of macromolecules involved in biological processes. Specifically, the group is looking at processes including proteins involved in cellular metal homeostasis, biomolecules involved in the immune response, and the DNA-binding domain (DBD) of the human vitamin D receptor (hVDR) and its complex with specific elements of DNA. The premise is that functional details are contained within a knowledge of the structure at atomic resolution. The computers at the Supercomputing Institute's Basic Sciences Computing Laboratory and numerous software packages are being used in this work. Software packages vnmr and nmrpipe are being used for NMR processing, x-plor is being used for structure calculations, and insight ii, molmol, macromodel, and grasp are being used for visualization and analysis of three-dimensional structures.

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