This project is using modeling tools to develop a feasible model of a 68-residue chimeraplast (a chimeric DNA/2'-O-MethylRNA molecule capable of inducing a point-mutational change in mammalian chromosomal DNA). Modeling tools will be used to predict two-dimensional nuclear magnetic resonance (NMR) observations from the chimeraplast to determine if solution of the three-dimensional structure is feasible by this method. If feasibility is indicated, the available programs will be used to analyze two-dimensional NMR data collected from chimeraplast in the high-resolution NMR facility.
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URL: http://www.msi.umn.edu/about/publications/annualreport/ar2000/depts/Biochem_MolBio_BioPhys/eccleston.html |
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