This research group developed sequence-based methods to detect remote protein sequence similarities (homologies) that are or are not indicative of protein structural and functional similarities. The methods were developed, tested, and evaluated using non-redundant pair wise test sets that contain proteins of known sequence and structure. The researchers emphasized identifying sequence pairs that have similar sequence with dissimilar structure and those that have dissimilar sequence with similar structure.
Edward Bryan, Research Associate
Paul Tavernier, Research Associate
Fei Xu, Research Associate
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