Rolf Gruetter, Principal Investigator

Analyzing Spectra Using One-Dimensional and Two-Dimensional Methods

This research group focused on analyzing spectra using one-dimensional and two-dimensional methods applied using the high-resolution nuclear magnetic resonance (NMR) facility and in vivo data. Specifically, the group is focused on detailing the information content of such spectra, spectral simulations, and the fitting of systems of 25 different equations to time courses measured in vivo . The research group is working to provide fundamental insights into the biochemical regulation of the brain and to understand the regulation of brain metabolism during hypoglycemia, which has been identified as the major roadblock in the treatment of diabetes. To this end, the group will:

• Pinpoint the modeling constraints that are necessary to determine the rate of neurotransmission in the brain in vivo
• Measure approximately 20 neurochemicals simultaneously in vivo from very small volumes

Research Group

Gulin Oz, Graduate Student Researcher
Ivan Tkac, Research Associate