Kristin A. Hogquist, Principal Investigator

Peptide Introduction of Positive Selection

Positive and negative selection are the critical forces that shape the T cell repertoire. These researchers addressed the molecular mechanisms of positive selection using a model system where defined peptide ligands can be used to preferentially induce one selection outcome or the other. Using confocal microscopy and gene array technology, the researchers attempted to identify the molecules integral to the processes of positive and negative selection of T lymphocytes.

Research Group

Timothy Starr, Graduate Student Researcher