Kristin A. Hogquist, Principal Investigator

Peptide Introduction of Positive Selection

Positive and negative selection are the critical forces that shape the T cell repertoire. This project addresses the molecular mechanisms of positive selection using a model system where defined peptide ligands can be used to preferentially induce one selection outcome or the other. These researchers use confocal microscopy and gene array technology to identify the molecules that are integral to the processes of positive and negative selection of T lymphocytes.