Intervention
Timing according to circadian stage can have drastically different effects and
hence can be used to optimize treatment when needed. For instance, the same
kind of surgery in the morning raises and in the afternoon lowers blood
pressure and heart rate. Blood pressure can vary spontaneously from being too
high to being acceptable, if not too low, during office hours. This resolution
and evidence amplifying on it tell us what to do about it. It proposes the
recycling of systematically collected, otherwise lost information and
chronobiologic action on this basis with self-help (29, 30).