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Session IV

3:00 - 5:00 p.m.

Poster Presentation and Refreshments in BSBE 2nd Floor
1)

Urinary (S)/(R)-p-Hydroxyphenyl phenylhydantoin ratios in epilepsy patients genotyped for CYP2C9 & CYP2C19 polymorphisms
Upendra Argikar, James C. Cloyd, Ilo E. Leppik, Angela K. Birnbaum, Jeannine Conway, Smita Kshirsagar and Rory P. Remmel1*.
University of Minnesota

2) Metabolism of Valproic Acid toits Glucuronide in Human Liver Microsomes
Upendra Argikar and Rory P. Remmel*.
University of Minnesota
3) Purification, Characterization and Crystallization of Bacterial Menaquinone Biosynthetic Enzymes
Yang Tian, Bernard D. Santarsiero and Andrew D. Mesecar*
University of Illinois at Chicago
4) An Unexpected Side Reaction Involving the Deletion of an Acetylated N-Methyl-Amino Acid from the N-Terminus of Peptides
W.-J. Fang, M.A. Bennett, T.F. Murray, and J.V. Aldrich,*
University of Kansas
5) Potent Anticancer OSW-1 Analogues: Synthesis and Structure Activity Relationship
Changgang Lou, Ying Kang, Zhendong Jin*
University of Iowa
6) Synthesis of DNA oligodeoxynucleotides containing structurally defined N6- (2'-hydroxy-3',4'-epoxybut-1'-yl)adenine adducts of 1,2,3,4-diepoxybutane
Danaè R. Quirk Dorr and Natalia Tretyakova*
University of Minnesota
7) Quantitation of p-Cresol Sulfate in PremproTM Tablets
Aarti Sawant, Benjamin M. Johnson, Judy L. Bolton, and Richard B. van Breemen*
University of Illinois-Chicago
8) Regioselective Single and Double Conjugate Additions to Substituted Cyclohexa-2,5-Dienone Monoacetals
Scott Grecian, Aaron D. Wrobleski, and Jeffrey Aubé*
University of Kansas
9) Synthesis of Fluoroquinol One-Based Probes for Bacterial Efflux Pump Inhibition
Nadezhda German, Peng Wei and Robert J. Kerns*
University of Iowa
10) Overcoming Drug Resistance Induced by BCL-XL Overexpression Using Small Molecule Inhibitors
Jignesh M. Doshi and Chengguo Xing*
University of Minnesota
11) The Molecular basis for the Health Benefits of Resveratrol and its Metabolites
Barbara Calamini, Bernie Santarsiero, Kiira Ratia and Andrew Mesecar*
University of Illinois at Chicago
12) Domino Reactions Towards Turn-Like Scaffolds and Their Application to Diversity-Oriented Synthesis
Erin E. Hirt, Yibin Zeng, Robyn Allyn and Jeffrey Aube’*
University of Kansas
13) Study of N-Acyl Heparin Derivatives that Bind Thrombin
Christopher M. Hattan and Robert J. Kerns*
University of Iowa
14) Protein-DNA Cross-Linking by Antitumor Nitrogen Mustards
Melissa Goggin, Rachel Loeber, Danaé Quirk Dorr, Mathur Rajesh, and Natalia Tretyakova*
University of Minnesota
15) Characterization of Two putative Glutamate Racemases from Bacillus anthracis
Melissa L. May, Bernard S. Santarsiero, Andrew D. Mesecar*, and Michael E. Johnson.*
University of Illinois at Chicago
16) Studies Towards the Total Synthesis of Ezomycins
Juhienah Khalaf and Apurba Dutta*
University of Kansas
17) Amino Acid Modification by 3,4-Dihydroxyphenylacetaldehyde, a Reactive Intermediate of Dopamine Metabolism
Jennifer N Rees, Virginia Florang, and Jonathan A Doorn*
University of Iowa
18) Rational Design and Synthesis of Interfacial Inhibitors of HIV-1 Integrase
Srikanth Kolluru, Ramaiah Muthyala* and Robert Vince*
University of Minnesota
19) Alkylating Specific Cysteines of the Human Electrophile-Sensing Protein KEAP1 does not Disrupt its Association with the NRF2 Domain NEH2
Aimee L. Eggler, Guowen Liu, John M. Pezzuto, Richard B. van Breemen, Andrew D. Mesecar*
University of Illinois-Chicago
20) A Novel Scaffold for Anti-Sepsis Drugs
Kriangsak Khownium, Stewart J. Wood, Thuan B. Nguyen, Kelly A. Miller, Gunda I. Georg*, and Sunil A. David*
University of Kansas
21) Chemical Investigation of Potential Antidepressants Based on Salvinorin A, a Potent κ Opioid Agonist from Salvia Divinorum
Matthew D. Schmidt, Kevin J. Tidgewell, Wayne W. Harding, Christina M. Dersch, Richard B. Rothman, and Thomas E. Prisinzano*
University of Iowa
22) Development of a sensitive method for quantitation of DNA pyridyloxobutylation adducts derived from the tobacco specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Yanbin Lao, Peter W. Villalta, Mingyao Wang, Guang Cheng, Shana J. Sturla, and Stephen S. Hecht *
University of Minnesota
23) In Silico Drug Screening and HTS by NMR to Discover Anthrax Protective Antigen Inhibitors
Oukseub Lee, Wentao Fu, Shaokai Jiang, Michael Caffrey, Michael E. Johnson*
University Illinois at Chicago
24) Stereoselective Total Synthesis of (2S,3R)-3-Hydroxypipecolic acid
Ningning Liang and Apurba Dutta*
University of Kansas
25) Microbial Sulfoxidation Using Immobilized Microorganisms. Oxidation of b-Sulfanyl Carboxylic Acids
Antonio Osorio-Lozada and Horacio F. Olivo*
University of Iowa
26) Cross-Linking of the Human DNA Repair Protein O6-Alkylguanine DNA Alkyl Transferase to its DNA Substrate in the Presence of 1,2,3,4 Diepoxybutane
Rachel Loeber and Natalia Tretyakova*
University of Minnesota
27) Interaction of Nascent Peptide with the Ribosomal Exit Tunnel
Nisha Shankaran, Marne J. Bailey and Alexander Mankin*.
University of Illinois at Chicago
28) Synthesis and Pharmacological Evaluation of Dual Labeled Delta Opioid Receptor Peptides
Angie M. Peck, V. Kumar, T.F. Murray, and J.V. Aldrich1*
University of Kansas
29) Progress on the Synthesis of the Auriside Aglycon
Rodolfo Tello-Aburto, Adrian Ochoa-Teran and Horacio F. Olivo*.
University of Iowa
30) Design and Synthesis of Metabolically Stable GSH-Analogs as Components of Prodrugs and Glyoxylase-I Inhibitors
Swati S. More, Ramaiah Muthyala* and Robert Vince*
University of Minnesota
31) Development of Novel Nitrates for Colon Cancer Chemoprevention
Ghenet K. Hagos, Violeta Toader, Daniel D. Lantvit, Steven Swanson, Robert E. Carroll, Gregory R.J. Thatcher*
University of Illinois at Chicago
32) Stereoselective Synthesis of a Novel Carbamoyl Oxybiotin
Christina S. Stauffer and Apurba Dutta*
University of Kansas
33) Enantioselective Synthesis of a Net-Selective Reboxetine Analogue
Wayne W. Harding, Mathis Hodge, Jeffrey R. Deschamps, Damon Parrish, Zhixia Wang, William L. Woolverton and Thomas E. Prisinzanoa*
University of Iowa
34) Carbo-Acyclic Nucleosides
Ye Tang, Ramaiah Muthyala, Robert Vince*
University of Minnesota
35) Initial Studies On Targeting the First Steps of Isoprenoid Biosynthesis Via the DXP Pathway for Drug Discovery Against Bacillus anthracis.
Patrick S. Miller and Andrew D. Mesecar*
University of Illinois at Chicago
36) Toward the Combinatorial Synthesis of a Library of Structurally Diverse Cyclo-Enaminones
Brandon J. Turunen; Timothy R. Ward; Gunda I. Georg*.
University of Kansas
37) Approach to the Syntheses of (-)-Stemoamide, (+)-Neostemonine, and (+)-Bisdehydroneostemonine
Ricardo Tovar-Miranda, Efraín Barragán, and Horacio F. Olivo*
University of Iowa
38) Efforts Toward Developing BCL-2 Member-Selective Modulators Through Solid Phase-Based Approach
Liangyou Wang, Xiaohu Tang, and Chengguo Xing*
University of Minnesota
39) High-throughput screening bioassay against Glutamate Racemase from Bacillus anthracis
Huidong Yu, Melissa May, Andrew Mesecar*, Michael Johnson*
University of Illinois at Chicago
40) The Design and Synthesis of Novobiocin Analogues as HSP90 C-Terminal Inhibitors
Xiao Ming Yu, Gang Shen, and Brian S. J. Blagg*
University of Kansas
41) Microbial Transformations of Selected Organosilanes
Shuvendu Das, Joe McAuliffe, Wyatt Smith and John P. N. Rosazza*
University of Iowa
42) α- and β- Naltrexamine Derivatives as Probes to Evaluate Opioid Receptor Dimerization
Jie Yang, Michael Powers, Anne Krieger and Philip S. Portoghese
University of Minnesota
43) Synthesis of Aminoinositol Analogs as Iinhibitors of PI-PLC and PI-3K
Hua Li and Karol S. Bruzik*
University of Illinois at Chicago
44) Estrogen Receptor-Mediated Cytotoxic Agents
Yaguo Zheng and Yusuf Abul-Hajj*
University of Minnesota
45) Synthesis of Mitochondrial Targeted Antioxidants
Nicolette Christa Ross, Brian Fink, William I. Sivitz, and Thomas E. Prisinzanoa,*
University of Iowa
46) Improving Catalytic Activity of an Organophosphate Degrading Enzyme via Random and Site-Directed Mutagenesis
Renda L. Hawwa, Sonia D. Larsen and Andrew D. Mesecar*
University of Illinois at Chicago
47) Characterization of Nicotinate Mononucleotide Adenyltransferase from Bacillus anthracis
Valerie C. Sershon and Andrew Mesecar*
University of Illinois at Chicago
48) Synthesis of Biotinylated Macrolide Derivatives for Use in Identifying Novel Binding Proteins
Phuongdiep L. Nguyen and Robert A. Fecik*
University of Minnesota

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