Christopher A. Lipinski

Dr. Lipinski retired from the position of Senior Research Fellow in the Exploratory Medicinal Sciences Department at the Pfizer Global Research and Development Groton Laboratories in June 2002. He received a B.Sc. degree in chemistry from San Francisco State College in 1965 and a Ph.D. in 1968 in physical organic chemistry from the University of California , Berkeley . He joined Pfizer in 1970 following a National Institutes of General Medical Sciences Postdoctoral Fellowship at the California Institute of Technology. At Pfizer from 1970 to 1990 he supervised medicinal chemistry drug discovery laboratories discovering multiple gastrointestinal and diabetic clinical candidates. In this process he became interested in the design of bioisosteres and in drug physical chemical properties and quantitative structure activity relationships, especially as they related to problems of oral activity. In 1990 he established a highly automated laboratory combining computations and experimental physical property measurements. Experimentally, his laboratory provided experimental solubility measurements on medicinal compounds synthesized at the Pfizer Groton site. Computationally he champions a very pragmatic, chemistry end user oriented, approach to the problem of oral activity improvement. He is a member of the Medicinal Chemistry section of the American Chemical Society, the American Association of Pharmaceutical Sciences, the Society for Biomolecular Screening and the European Federation of Pharmaceutical Sciences. He serves on the scientific advisory board for the Global Alliance for TB Drug Development, ASDI Biosciences and the Matrical company and is a consultant for the Hereditary Disease Foundation. He is a member of the editorial board of the journal of Pharmaceutical Sciences and the highlights advisory board of Nature Reviews Drug Discovery and the advisory boards of several other journals. He is the American Chemical Society's 2005 winner of the E. B. Hershberg Award for Important Discoveries in Medicinally Active Substances and the 2004 winner of the Division of Medicinal Chemistry Award of the ACS Division of Medicinal Chemistry. Since 1984, he has been an adjunct faculty member at Connecticut College in New London CT , and has over 200 publications and invited presentations and 17 issued US patents.