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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Cheryl A. Gale

Polarity Establishment Mechanisms in Candida albicans

The Gale laboratory studies the molecular mechanisms of morphogenesis in the opportunistic fungal pathogen, Candida albicans. By using molecular and cell biological approaches, they hope to dissect the differences that underlie yeast- and hyphal-form growth and to understand how the filamentous hypha, in particular, facilitates tissue invasion. Specific research projects involve identifying and characterizing the role of hyphal tip-localized polarity proteins in morphogenesis, growth tropisms (directional growth in response to an environmental signal), and tissue invasion and virulence using in vitro tissue culture models as well as in vivo models of candidiasis. In addition, time-lapse fluorescence microscopy is being used to characterize the temporal and spatial localization requirements of polarity proteins throughout the cell cycle, during the transition between morphologic forms, and with alteration in hyphal growth direction.

Group Members

Rebecca Pulver, Graduate Student
Timothy Heisel, Staff
Jennifer Norton, Staff
Christina Falgier, Graduate Student
Kendra Van Beusekom, Undergraduate Student
Sara Kegley, Undergraduate Student