Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
Department of Obstetrics, Gynecology, and Women’s Health
PI: Melissa A. Geller
Co-PI: Amy P. Skubitz
Investigations Into Ovarian Cancer Chemotherapy Treatment
Epithelial ovarian cancer remains the leading cause of death from gynecologic cancers in spite of extensive efforts at therapeutic and surgical intervention and recent advances in biologic agents. The standard treatment for ovarian cancer, surgery and chemotherapy, yields a five-year overall survival of less than 30% for patients with advanced-stage disease. These researchers are investigating whether chemotherapy is selecting out chemoresistant cells that will acquire DNA mutations translating into altered gene expression and mutated proteins. Their goal is to be able identify women who would derive little benefit from debulking surgery and standard chemotherapy and those who would recur early. Thus, physicians would be able to use alternative therapies targeting molecular pathways on these women.
The three aims of this project are: to determine if biomarker patterns change as a result of treatment with chemotherapy; to determine changes in tumor genomic composition obtained before and after chemotherapy; and to determine if the presence of certain biomarker and extreme drug resistance assay profiles will predict the ability to perform optimal cytoreduction.
Lisa M. Rogers, Staff