Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
Department of Pediatrics
PI: Michael K. Georgieff
Altered CA1 Hippocampus Apical Dendrite Morphogenesis Due to Early Iron Deficiency Anemia
Using a dietary model in Sprague Dawley rats of gestational/neonatal iron deficiency, the Georgieff laboratory has demonstrated structural, biochemical, electrophysiological, and behavioral changes in the developing hippocampus. The high energy demands of the developing hippocampus make it particularly vulnerable to iron deficits. The researchers are investigating how early iron deficiency alters branching and spine growth trajectories, short term and long term. They use software available at the BSCL to deconvolute spine images in order to better visualize spine morphology.
Katyarina Brunette, Graduate Student