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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Timothy J. Griffin, Associate Fellow

Proteomic Analysis Using Mass Spectrometry

In the evolving era of genome biology, mass spectrometry has emerged as a leading tool by which to measure the various properties of the protein products expressed by the genome. The complexity of biological systems, however, continually proves challenging to these existing methodologies, necessitating the development of novel tools to obtain the information required to gain a comprehensive understanding of these systems. The Griffin laboratory is interested in developing proteomics methods using mass spectrometry to investigate mechanisms of cellular regulation and protein function. Among the ongoing projects in this laboratory is the development of free-flow electrophoresis as a high-resolution separation tool, and application of this method to saliva proteomics and oral cancer detection. Another project involves the development of a novel approach to study the dynamics of chromatin-associated proteins and protein complexes, providing new insights into a fundamental mechanism of cellular regulation. A third area of research is the development of a novel approach to study oxidative-stress-induced carbonyl modification of proteins, providing new insights into an important aspect of cellular damage implicated in aging and disease.

Group Members

Sri Bandhakavi, Research Associate
Xiaobing Chen, Visiting Researcher
Ebbing de Jong, Research Associate
Joel Kooren, Graduate Student
Pontus Lundemo, Visiting Researcher
Getiria Onsongo, Graduate Student
Mikel Roe, Graduate Student
Matt Stone, Research Associate
Sue van Riper, Graduate Student