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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Microbiology

PI: Ashley T. Haase

Functional Genomic Analysis HIV-1 Infected Lymphatic Tissue

This group uses microarrays to profile gene expression in lymph node biopsies. They most recently have focused on changes in gene expression in HIV-1 infected subjects compared to uninfected individuals in the acute, pre-symptomatic and AIDS-stages of infection. They discovered stage-specific gene expression signatures with the greatest number of changes in the acute stage of infection where there is increased expression of numerous type I and II interferon system, natural killer cell, and other innate immunity system genes. This group is now looking at correlations between changes in gene expression and viral load and depletion of CD4+ T cells, and they are mapping genes in lymph nodes and other tissues to gain insight into normal function and pathology.

Group Members

Timothy Shacker, Faculty Collaborator
Cavan Reilly, Faculty Collaborator
John Carlis, Faculty Collaborator
Qingsheng Li, Research Associate
Anthony Smith, Research Associate