Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
Department of Laboratory Medicine and Pathology
PI: Franz Halberg, Associate Fellow
PI: Germaine G. Cornélissen
Assessment of Physiologic Chronomes From Womb to Tomb
Strokes and other adverse vascular events are major cripplers at an estimated yearly cost of over $30 billion. These researchers are developing a system for the chronobiologic analysis of cardiovascular records with focus on disease prevention, but also addressing the question of the optimal kind and scheduling of treatment. Ambulatory devices are used in different geographic locations to monitor blood pressure for seven days at the outset. Chronobiologic analyses of such records serve first and foremost to improve screening, diagnosis, and treatment, but also to assess how environmental factors affect human physiology, notably heart rate and blood pressure. In addition to known photic solar effects (day/night, seasons), non-photic effects (including magnetoperiodisms) may account for about 16- and 5-month cycles also observed in the incidence of sudden cardiac death and in the occurrence of ventricular arrhythmia triggering therapy from defibrillators in Minnesota.
The researchers use supercomputing resources to: analyze long and dense data series; automatically update reference standards as added data accumulate; detect the earliest risk by means of chronome (time structure) alterations; follow up at-risk individuals longitudinally by means of control charts; and explore large-parameter spaces in nonlinear analyses not requiring the specification of initial values.
Jerzy Czaplicki, Institute of Pharmacology and Structural Biology, Paul Sabatier University, Toulouse, France
Dewayne Hillman, Halberg Chronobiology Center, University of Minnesota, Minneapolis, Minnesota
Miguel A. Revilla, Department of Applied and Computational Mathematics, Faculty of Sciences, University of Valladolid, Valladolid, Spain