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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Reuben S. Harris

Genomic Investigations of Mammalian APOBEC Proteins

The APOBEC gene family provides a broad defense against various endogenous and exogenous viruses and transposable elements. This defense system seems to have evolved during the mammalian lineage, from one gene in mice to seven in humans. These researchers are undertaking a comparative analysis of the APOBEC locus in several organisms. This will allow them to understand how this important gene family evolved and how this evolution relates to the different functions of the APOBEC proteins of different organisms. The researchers use bioinformatics tools available at the CGL to help them assemble sequencing data from large-scale sequencing projects and to perform bioinformatics analyses of the resulting data.

The Harris group also collaborates with the group of Associate Professor Hiroshi Matsuo (Biochemistry, Molecular Biology, and Biophysics) on their research into how human APOBEC3G interacts with the HIV genome.

Group Members

Stefan Jonsson, Graduate Student
Rebecca LaRue, Graduate Student
Mark Stenglein, Graduate Student