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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Genetics, Cell Biology, and Development

PI: Tom S. Hays

Studies on the Structure and Phosphoregulation of Cytoplasmic Dynein

These researchers study the phosphoregulation of Drosophila cytoplasmic dynein and tested the hypothesis that phosphorylation of subunits can regulate dynein targeting and function. Previous studies of dynein phosphorylation are limited, the identified sites are controversial, and no studies have been approached in a genetically tractable system where the function of sites can be tested. In collaboration with Dr. John Yates (Scripps Research Institute), these researchers are using mass spectrometry to analyze the sites of subunit phosphorylation in the Drosophila cytoplasmic dynein complex. Their priority is the identification of phosphorylation sites within the IC, LIC, and LC subunits that may function in cargo attachment.

The researchers use software at the BSCL, CGL, and SDVL for sequence analysis and comparisons.

Group Members

Yungui He, Research Associate
Mingang Li, Research Associate
Lingzhi Ma, Staff
Sarah Mische, Research Associate