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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathology

PI: Kristin A. Hogquist
Co-PI: Stephen C. Jameson

Thymic Selection

T lymphocytes acquire their essential characteristics during development in the thymus.  These properties—clonal expression of antigen receptors, major histocompatibility complex (MHC) restriction, self-tolerance, and lineage specific effector function—are continually established in the thymus as progenitors develop throughout the life of the animal. These researchers study how MHC restriction and self-tolerance are imprinted using genetically engineered mouse models. Current approaches include flow cytometry, microarrays, and fluorescent imaging; the group uses the BSCL, CGL, and SDML.

Group Members

Tom McCaughtry, Graduate Student
Amy Moran, Graduate Student
Kensuke Takada, Research Associate
Mike Weinreich, Graduate Student
Yan Xing, Research Associate