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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Alan B. Hooper

The Characterization of the Membrane cty cm552 and Its Structure Based on Homology Modeling

A high-sequence similarity between cyt cm522 and the NrfH protein from the bacterium Desulfovibrio vulgaris permitted a homology model construction of cyt cm552, allowing comparisons of potential key residues in and around the active site with respect to the presumed quinol reductase function of cyt cm 552. This project will further refine the model of cm552 including incorporation of metallocenters using the Insight modeling package. The work will extend to analyzing potential substrate and active site residue interactions.

Group Member

Hyung J. Kim, Research Associate