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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Laboratory Medicine and Pathology

PI: Stephen C. Jameson

Regulation of Gene Transcription by Mouse Kruppel-like Factor 2

Kruppel-like faction 2 (KLF2) is a member of a family of transcription factors with well-defined DNA binding domains. This researcher has analyzed the role of KLF2 in regulating genes important in the proliferation and function of mouse lymphocytes. This project uses the CGL to identify new potential targets for KLF2 binding and to characterize likely intersections with other transcriptional regulatory pathways.