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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Pharmacy
Department of Medicinal Chemistry

PI: Rodney L. Johnson

Design of Peptidomimetics of the Dopamine Receptor Modulator Pro-Leu-Gly-NH2 and of a Smac Peptide Fragment as Inhibitors of Apoptosis

These researchers are designing and synthesizing conformationally constrained peptidomimetics of the dopamine receptor Pro-Leu-Gly-NH2. The peptidomimetics are used to construct a pharmacophore model of the modulatory site. Peptidomimetic photoaffinity labeling agents are made in order to label the modulatory binding site and to use the G protein-coupled receptor model of the dopamine receptor to identify the modulatory site on the receptor. The group has also designed and synthesized peptidomimetics of the Smac fragment AVPI based on a model of AVPI bound to the BIR3 binding site of the apoptotic protein XIAP. The researchers are using the BSCL and the BMSDL for this project.

Group Members

Swapna Bhagwanth, Graduate Student
Ziaochun Dong, Research Associate