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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Microbiology

PI: Vivek Kapur

Investigations on Bacterial and Viral Pathogens: Pathogenomics

The focus of this research program is to understand the basic processes by which bacteria and viruses cause disease and how their hosts respond to infection. To address this problem, the researchers apply genomics tools, including whole-genome sequencing, expression profiling using microarrays, and proteomics, to characterize microbial pathogens and the host response to infection. The group has sequenced several bacterial genomes, including Pasteurella multocida, Lawsonia intracellularis, Staphylococcus aureus, and Mycobacterium avium subsp. paratuberculosis. They have also recently re-sequenced a virulent isolate of Pasteurella multocida. They use Supercomputing Institute resources for annotation of more genomes of bacterial and viral pathogens, for analysis of microarray data on gene expression and comparative genomics, and to investigate strain differentiation within species.

Group Members

Alongkorn Amonsin, Research Associate
Lisa Herron, Graduate Student
Kuljeet Kaur, Research Associate
Shirin Munir, Research Associate
Garret Olson, Graduate Student
Qing Zhang, Research Associate
Barbara May, Research Associate