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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Biochemistry, Molecular Biology, and Biophysics

PI: Romas Kazlauskas, Associate Fellow

Catalytic Plasticity in Enzymes

Enzymes evolve into new enzymes by acquiring new catalytic abilities. These researchers are mimicking this process in the laboratory to create new enzymes for organic synthesis. They are using the BSCL and the CGL to perform molecular modeling and visualizations.

The group has recently modeled the enantioselectivity of subtilisin and is now working to identify the origin of the catalytic plasticity of subtilisin for chiral sulfur compounds.

Group Members

Peter Bernhardt, Department of Organic Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts
Kurt Faber, Institute of Organic Chemistry, University of Graz, Graz, Austria
Sara L. Fossum, Supercomputing Institute Undergraduate Intern
Ryota Fujii, Research Associate
Tatsiana Gerassenkov, Undergraduate Student
Yun Jiang, Graduate Student
Qing Jing, Research Associate
Paul Mugford, Department of Chemistry, McGill University, Montreal, Quebec, Canada
Santosh Padhi, Research Associate
Chris Savile, Graduate Student
Tyler Yin, Graduate Student
Dahai Yu, Staff