Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Biochemistry, Molecular Biology, and Biophysics
PI: Do-Hyung Kim
Structural Studies on mTOR
Mammalian target of rapamycin (mTOR) is known as the emerging point for two important nutrient and growth factor signaling pathways, the insulin signaling pathway and the mTOR signaling pathway. Structural understanding of the mTOR complex is one of the essential tools for insulin/mTOR signaling pathway in the cell. The goal of this project is to understand the structure and function of mTOR and its complexes in the mTOR signaling pathway.
The researchers use resources at the BSCL and BMSDL to solve mTOR and its complex structures as well as the structures’ functions in the mTOR signaling pathway. Once structural information for mTOR domain proteins and their complex proteins is identified, it may be used for therapeutic drug targets for obesity, diabetes, and cancer.
Seung-Hyun David Ro, Graduate Student