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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Food Science and Nutrition

PI: Catherine M. Kotz

Microarray Analysis of Brain on Obesity-prone and Obesity-resistant Rats

These researchers are using MSI laboratories to analyze microarray data obtained from four specific brain nuclei in obesity-prone and obesity-resistant rats. These data have already been generated using University-sponsored Affymetrix chips. The researchers are performing pattern analysis on the data.

Earlier in this period, this group worked on a project to determine how the brain controls physical activities like fidgeting and other involuntary movements to assess the influence of these activities on body weight. The group’s overall goal was to find a solution for the escalating problem of obesity and type 2 diabetes. Specifically, they investigated orexin, a potential stimulant of "fidget-like” activities in people who are able to resist weight gain, and attempted to determine changes in calorie burning when manipulating brain orexin.

Group Members

Mark Margosian, Staff
Josh Nixon, Graduate Student