Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
School of Public Health
Division of Biostatistics
PI: Na Li
HyperGEN: Genetics of Left Ventricular Hypertrophy
Left ventricular hypertrophy (LVH) is a common phenotype, occurring in up to 60% of hypertensives, that is associated with significant cardiovascular mortality. This researcher is expanding on previous investigations of LVH within persons with hypertension; that research identified several LVH linkage regions in the genome. This project will further refine the linkage results by conducting linkage analyses that include the offspring of the hypertensive siblings who were recently genotyped by the Mammalian Genotyping Service (genotypes were released in October 2005). Linkage analysis with these larger pedigrees will provide better power than was available previously. The hypothesis is that there are genetic variants that play clinically significant roles in LVH and that will suggest novel pathways for LVH preventive or therapeutic interventions.