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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Psychiatry

PI: Kelvin O. Lim

White Matter Abnormalities in Schizophrenia

The overall objective of this study is to use structural neuroimaging, neurocognitive assessments, and genetic data (single nucleotide polymorphisms) to characterize brain differences associated with schizophrenia and other neuro-psychiatric conditions. Schizophrenia has long been classified by both positive and negative behavioral symptoms (hallucinations, delusions, and flat affect) as well as remarkable brain-structure remodeling, specifically gray matter tissue loss. Recent work in the Lim laboratory, however, has also shown white matter abnormalities in patients with schizophrenia. The researchers are analyzing MRI images to study aspects of macrostructural tissue and white matter microstructure.

Group Members

Chris Bell, Staff
Daniel Franc, Graduate Student
Bryon Mueller, Faculty Collaborator
Ryan Muetzel, Staff
Miranda Nelson, Staff
Paul Robinson, Staff