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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Genetics, Cell Biology, and Development

PI: York H. Marahrens

Role of Repetitive Sequences in Human Disease

These researchers are examining the relationship of repetitive sequences and other epigenetic elements to gene expression levels. They have analyzed hundreds of published datasets and, in a preliminary manner, identified several common human diseases where they associated abnormal gene expression in the diseases to abnormal influences of repetitive sequences on gene expression levels. In other words, repetitive sequences are known to be capable of influencing the expression levels of nearby genes. In the aforementioned diseases, mutations, susceptibility loci, or other factors, such as environmental stress, are thought to have altered the states of repetitive sequences and, in turn, altered the expression levels of certain gene sets in a predictable manner. The group is using resources at the CGL to prepare datasets that are too large for conventional computers and to run scripts that are to intensive for conventional computers.

Group Member

Wuming Gong, Graduate Student