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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary and Biomedical Sciences

PI: James R. Mickelson

Genetic Linage Analysis of Heritable Neuromuscular Disorders in Domestic Animals

Simple and complex heritable diseases are relatively common in companion animal species due to selected breeding schemes that use common founders and family lines to propagate highly desirable traits. These researchers use genetic linkage and genetic association analyses to begin to identify the genetic loci responsible for a number of heritable disorders in dogs and horses. The researchers obtain genotypes for microsatellite or single nucleotide polymorphism DNA markers located at evenly spaced intervals across the genome and analyze them for statistically significant linkages or associations to the trait in large, often-complex pedigrees or populations. By identifying DNA markers that co-segregate with the trait, the researchers can essentially map the gene for the trait to that region of a specific chromosome represented by that marker where the gene can ultimately be identified. The researchers are also taking part in the equine genome mapping effort where a major goal is to construct a comparative horse-human genome map. The researchers used the CGL for this project.

Group Members

Kari Ekenstedt, Graduate Student
Molly McCue, Faculty Collaborator
Katie Minor, Staff
Ned Patterson, Faculty Collaborator