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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Jeffrey S. Miller

Use of Gene Arrays to Understand the Biology of Human Natural Killer Cells

Despite progress made in the understanding of Natural Killer (NK) cell development, the molecular mechanisms directing differentiation of NK cells and killer-immunoglobulin receptor acquisition during development are poorly understood. This researcher has found that FEZ1 (fasciculation and elongation protein zeta 1), JFC1(C2 domain-containing protein), granzyme M, ATP2A3 (ATPase), CLIC3 (chloride intracellular channel 3), CTL2, PTR4 (peptide-histidine transporter 4), and EDG8 (G-protein-coupled receptor 8) were commonly up-regulated in the more mature NK cell populations and STAT1, NME2 (non-metastatic cells 2), SEC14L1 (SEC14-like 1), RGS16 (regulator of G-protein signaling 16), FUT8 (fucosyltransferase 8) were down-regulated. He used the CGL to study this small list of genes further to understand the final stages of NK cell maturation and elucidate a developmental link between the two best characterized NK cell subsets circulating in blood.