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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Duluth
College of Pharmacy Duluth
Department of Pharmacy Practice and Pharmaceutical Sciences

PI: Ayman M. Noreddin

Pharmacokinetic and Pharmacodynamic Modeling; Pharmacogenetic and Clinical Simulation Analysis of Chemotherapeutic Agents

This work aims to model the pharmacokinetics (PK) and pharmacodynamics (PD) of several fluoroquinolones against several genetically identified mutants of Streptococcus pneumoniae. Several PK and PD distribution values are being entered into Monte Carlo simulation routines. The researchers then conduct clinical simulation and prediction analysis to predict activity of the fluoroquinolones against different genetic variables expressed by the resistant mutants.

Group Members

Walid F. El-Khatib, Research Associate
Ahmed H. Salem, Graduate Student