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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Institute of Technology
Department of Biomedical Engineering

PI: David J. Odde, Associate Fellow

Computational Cell Motility

These researchers are simulating various cytoskeletal and signaling processes involved in cell division and growth. For example, microtubules are linear, self-assembled polymers that control intracellular organization and transport, and their assembly is a highly regulated process. This group uses Monte Carlo simulations to test various theories about how microtubules assemble and how the assembly is controlled in the cell. They are also interested in how kinase/phosphatase and GEF/GAP systems control cell motility. Specifically, they are investigating the role of spatial gradients generated by these reaction-diffusion systems.

Group Members

Andrew Bicek, Graduate Student
Brian Castle, Graduate Student
Clarence Chan, Graduate Student
Melissa Gardner, Graduate Student
Nathan Henderlite, Undergraduate Student
Doninique Seetapun, Graduate Student
Erkan Tuzel, Collaborator