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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Erik J. Peterson

A Distinct Inflammatory Gene Expression Profile in Patients With Psoriatic Arthritis

Psoriatic arthritis (PsA) is a systemic inflammatory condition featuring polyarthritis associated with skin psoriasis. Apart from clinical indicators, few biomarkers are available to aid in the diagnosis and management of PsA. These researchers are interested in determining whether gene expression profiling in blood might provide new insights into pathogenesis of the disease. They have compared whole blood gene expression profiles in PsA patients and have discovered 310 differentially expressed genes, the majority of which were upregulated in patients compared to controls. The PsA expression profile does not significantly overlap with the profiles derived from two other inflammatory diseases, rheumatoid arthritis and systemic lupus erythematosus. The researchers’ findings have provided hypotheses to test in future studies.

Group Members

Joanna Dluzniewska, Adjunct Faculty
Ian Harmon, Research Associate
Liangxing Zou, Research Associate