Research Abstracts Online
2008 - March 2009
University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Genetics, Cell Biology, and Development
PI: Ann E. Rougvie
Caenorhabditis Genetics Center; Temporal Control of Development in Caenorhabditis elegans
These researchers use MSI resources to study the nematode Caenorhabditis elegans, a developmentally simple organism. One goal is to collect, maintain, and distribute nematode strains to the international scientific community.
They are also studying C. elegans to understand how cells execute specific events at precise times during development. Specifically, they dissect the timing mechanism that restricts the differentiation of hypodermal cells to a time late in the life of the worm, the transition from the larval to adult form. The approach is to identify mutations that cause this event to occur at the wrong time during development, and then to study the genes defined by these mutations. These genes are referred to as "heterochronic” genes because their mutation alters the relative timing and sequence of many developmental events in the animal. The long-term goal of this research is to determine how developmental timing mechanisms are integrated with the spatial and sexual cues required for proper development of metazoans.
Tamar Resnick, Staff
Bradley Scutvick, Staff
Theresa Stiernagle, Staff