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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Surgery

PI: Daniel A. Saltzman

Studies of Attenuated Salmonella With IL-2 Against Cancer

Oral inoculation with a nontoxic, attenuated strain (ΔcyA, Δcrp) of Salmonella typhimurium transformed with the gene for human IL-2 reduced tumor burden and improved survival in a mouse model of metastatic colon cancer in both a treatment and prophylactic murine experiment metastasis model. These effects appear to be mediated by Salmonella-induced increases in circulating and hepatic NK1.1+ lymphocytes as well as a variety of induced systemic cytokines. In addition, a similar NK cell response occurs in neuroblastoma and osteosarcoma experimental tumor models. The purpose of this project is to further characterize the local and systemic immune response as well as an intracellular anti-tumor mechanism of S. typhimurium with a gene for human IL-2 in experimental models of hepatic, pulmonary metastases, and neuroblastoma solid tumors. The researchers use resources of the Supercomputing Institute to plan and analyze genetic engineering aspects of this work.

Group Members

Lance B. Augustin, Research Associate
Natalie L. Frykman, Staff
Karen A. McCulloch, Staff
Brent S. Sorenson, Graduate Student
Mark D. Williams, Research Associate