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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Academic Health Center
Center for Drug Design

PI: Yuk Sham

Modeling, Simulation, and Structure Based Drug Design

Many diseases can be treated by the inhibition of protein targets that play an essential role in the life cycle for a virus, bacteria, or cancer cells. This group is interested in developing consistent and accurate computational approaches to understanding the molecular recognition process that plays a critical role in cellular signaling and enzyme catalysis. The ability to quantify analytically these protein-protein and protein-substrate interactions will provide an insight on how these therapeutic targets selectively bind as well as the rational basis to structure based drug design. Presently, this group is working on protein targets that are important for the treatment of AIDS, bacterial infection, and cancer.  

Group Members

Hiqmet Kamberaj, Research Associate
Garrett T. McLean, Supercomputing Institute Undergraduate Intern
Sergey Negrashov, Undergraduate Student
Jake Stricherz, Undergraduate Student