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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Population Medicine

PI: Srinand Sreevatsan

Functional Characterization of Iron Dependent Regulator of Bovine and Ovine Strains of Mycobacterium avium subsp. paratuberculosis

Mycobacterium avium subsp. paratuberculosis (Maptb) is an important animal pathogen whose genome has been sequenced at the University of Minnesota. Population genetic framework has revealed that Maptb is genotypically diverse. To understand the molecular basis of this variation at the host-pathogen interface, these researchers have analyzed the global gene expression profiles of the pathogen and the host. They utilized microarrays and a technique called "selective capture of transcribed sequences.” The researchers used MSI resources for the microarray data analyses and data interpretation.

As an ongoing effort to understand the functional genomics of Maptb, the current studies in the laboratory are designed to decipher the transcriptional machinery of the pathogen.

Group Members

Ramakrishnan Muthannan Andavar, Research Associate
Sajan George, Graduate Student
Lance Hellstrom, Graduate Student
Harish K. Janagama, Graduate Student
Deepti Joshi, Graduate Student
Raghavendra Joshi, Graduate Student
Abirami Kugadas, Graduate Student
Elise Lamont, Graduate Student
Ping Wang, Research Associate