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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Biological Sciences and Medical School
Department of Genetics, Cell Biology, and Development

PI: Daniel F. Voytas

Transposable Element Target Specificity

Transposable elements are discrete pieces of DNA capable of changing chromosomal position. Although transposable elements make up the majority of genomic DNA in most organisms, little is known about how they select integration sites. A comprehensive analysis of transposable element target site biases is being carried out in the yeast Saccharomyces cerevisiae. Two different transposable elements, called Ty1 and Ty5, are being analyzed. Ty1 is known to integrate near sites of RNA polymerase III transcription. Ty5, on the other hand, prefers to integrate in heterochromatin at the ends of chromosomes. Recent advances in DNA sequencing technology makes it possible to characterize many thousands of unique transposable element insertions. It is anticipated that high-throughput sequencing methods will make it possible to better understand factors that influence transposable element target site choice.

Group Members

Jiquan Gao, Roy J. Carver Co-Laboratory, Iowa State University, Ames, Iowa
Fengli Fu, Roy J. Carver Co-Laboratory, Iowa State University, Ames, Iowa