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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
Medical School
Department of Pediatrics

PI: Sing Sing Way

T Cell Priming and Differentiation After Listeria monocytogenes Infection

Selective T cell priming and expansion in an antigen-specific fashion is required for the rational design of vaccines aimed at priming T cell-mediated immunity. Using infection with the intracellular bacterium, Listeria monocytogenes, these researchers aim to dissect the in vivo requirements for pathogen-specific T cell priming, expansion, and differentiation after in vivo infection conditions. They are using microarray technology to probe to inflammatory cytokine conditions triggered by primary Listeria infection that result in priming pathogen-specific T cell immunity after infection.

Group Members

James Ertelt, Research Associate
Tanner Johanns, Graduate Student
Jared Rowe, Graduate Student