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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Veterinary Medicine
Department of Veterinary Clinical Sciences

PI: Vicki L. Wilke

A Pilot Study to Determine the Molecular Characterization of Canine Follicular Thyroid Carcinoma

Prognosis for thyroid carcinomas is dependent on tumor size, degree of tissue invasiveness, and evidence of metastasis. A large, more invasive tumor with evidence of metastasis at the time of diagnosis is associated with a worse prognosis. Follicular thyroid carcinomas (FTC) are the most common thyroid carcinoma cell type in dogs. This project’s hypothesis is that there are specific gene expression patterns associated with an FTC’s ability to be invasive vs. non-invasive and that these differing expression patterns can be capitalized upon to allow the development of therapeutic modalities for modifying disease outcome. The researchers are therefore genotyping invasive and non-invasive FTC by microarray analysis. They are using microarray analysis to evaluate invasive FTC and non-invasive FTC. Based on the results of this pilot study, results of the array analysis will be independently validated by measuring expression levels of selected genes individually. This will be performed using quantitative real-time reverse transcriptase polymerase chain reaction on the same tumor samples.

Group Members

Aelxa Hart, Staff
Kristy Metivier, Graduate Student
Charlie Seiler, Staff
Katja Wucherer, Research Associate