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Research Abstracts Online
January 2008 - March 2009

University of Minnesota Twin Cities
College of Pharmacy
Department of Medicinal Chemistry

PI: Chengguo Xing

Studies of the Binding Interactions of Small Molecules With Bcl-XL

Bcl-XL is an anti-apoptotic protein that prevents apoptosis by dimerizing with pro-apoptotic proteins to antagonize the pro-apoptotic activity. One of this group’s research efforts focuses on developing organic inhibitors to bind to Bcl-XL, preventing its antagonizing interaction with pro-apoptotic proteins. This research focuses on characterizing the binding interactions of such small molecules with Bcl-XL protein. Such structural information would guide further optimization of the Bcl-XL inhibitors.

Group Members

Sadiya Addo, Graduate Student
Sonia Das, Graduate Student
Jignesh Doshi, Graduate Student
David Hermanson, Graduate Student
Thomas Johnson, Graduate Student