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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Surgery

PI: Gregory J. Beilman

Identification of Biomarkers Using Metabolomics in Hemorrhagic Shock

Hemorrhagic shock, a result of acute blood loss, accounts for about half of the 150,000 deaths in the U.S. attributed to traumatic injury annually and is often a priming event for the development of multiple organ failure. Adaptive cellular mechanisms that accompany hemorrhagic shock and the subsequent developments are not well understood.  Metabolomics, the study of the repertoire of small molecules that arises during the process of metabolism, can be used to study and/or identify these adaptive cellular mechanisms.

These researchers obtain NMR spectra from urine, serum, muscle, and liver collected during the shock and recovery protocol. They then use the software program Chemomx, available through MSI, to assign a metabolite to each visible peak in urine and serum NMR spectra. During this period, they have analyzed ~200 urine spectra and ~300 serum spectra and are continuing their analysis.

Additionally, the group uses MSI resources to host their database and website. Currently the data is being entered via the website into the database. Development of automated data extraction from the database and using SAS server to extract and analyze the data is currently ongoing.

Group Members

Dan Lexcen, Graduate Student
Beth Lusczek, Graduate Student
Kristine Mulier, Research Associate
Priyaranjan Tokachichu, Graduate Student
Nancy Witowski, Research Associate