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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Biological Sciences
Medical School
Department of Genetics, Cell Biology, and Development

PI: Judith G. Berman

Global Genomic Analysis of Candida albicans Transcription Profiles, Genome Stability, and Centromere Function

This group studies the human pathogenic fungus Candida albicans. They analyze global patterns within large sets of transcription profiles and also analyze the DNA content of clinical and laboratory strains that have undergone genome changes using Comparative Genome Hybridization (CGH). CGH has revealed a number of aneuploidies in strains, and especially in strains resistant to specific anti-fungal drugs. In addition, the Berman lab discovered that centromeres, the chromosome regions responsible for segregation to both daughter cells, can move long distances within a chromosome to form "neocentromeres.” They are using chromatin immunoprecipitation coupled with massively parallel sequencing to analyze the DNA positions of neocentromeres. They then develop models for the sequence components that contribute to centromere/neocentromere positioning.

Group Members

Darren Abbey, Graduate Student
Shelley Applen, Undergraduate Student
Kelly Bouchonville, Graduate Student
David Bruck, Undergraduate Student
Laura Burrack, Research Associate
Hannah Chen, Staff
Gretchen Freed, Undergraduate Student
Carrie Ketel, Research Associate
Amnon Koren, Research Associate
Tamar Lahav, Research Associate
Katherine Matter, Staff
Mark McClellan, Staff
Maryam Nejad, Staff
Karl Petersen, Staff
Karen Tang, Research Associate
Hung-Ji Tsai, Graduate Student