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Burton_FH

Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Pharmacology

PI: Frank H. Burton

Oligonucleotide Biogenesis

These researchers are performing three-dimensional modeling, in Maestro, of theoretical non-replicative RNA oligonucleotide reproduction complexes. These complexes are selected on the basis of their theoretical structural capacity to facilitate or catalyze random oligonucleotide polymerization and non-random template reproduction, and on the basis of the NAMD- and Macromodel-calculated energy states of their potential alternate conformations based on phosphate-backbone bond rotation. The researchers are using several of the MSI laboratories for this project.

Group Member

Matthew T. Stuart, Undergraduate Student