University of Minnesota
University Relations

Minnesota Supercomputing Institute

Log out of MyMSI

Research Abstracts Online
January 2009 - March 2010

Main TOC ....... College TOC ....... Next Abstract

University of Minnesota Twin Cities
Medical School
Department of Pharmacology

PI: Frank H. Burton

Oligonucleotide Biogenesis

These researchers are performing three-dimensional modeling, in Maestro, of theoretical non-replicative RNA oligonucleotide reproduction complexes. These complexes are selected on the basis of their theoretical structural capacity to facilitate or catalyze random oligonucleotide polymerization and non-random template reproduction, and on the basis of the NAMD- and Macromodel-calculated energy states of their potential alternate conformations based on phosphate-backbone bond rotation. The researchers are using several of the MSI laboratories for this project.

Group Member

Matthew T. Stuart, Undergraduate Student