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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Food Science and Nutrition

PI: Chi Chen

Metabolomics of Hepatocarcinogenesis Induced by Peroxisome Proliferators

Incipient metabolomics technology possesses the power of biomarker identification through monitoring the global changes of biofluid/tissue metabolomes, and carcinogen sensitive/resistant mouse models originated from genetic engineering provides a unique platform for studying pathways of carcinogenesis. In this study, the researchers combine the LC-MS-based metabolomics technology and genetically-modified mouse models to investigate the mechanism of species-specific hepatocarcinogenesis induced by peroxisome proliferators through comparing the metabolomic changes in wild-type, mPparĀ·-null and humanized PPARĪ± mice following short-term and long-term fenofibrate treatments. Potential discovery of biomarkers for peroxisome proliferation and hepatocellular proliferation will have important applications in disease diagnosis and therapeutics, and in cancer risk assessment.

Group Members

Darin Schwinkendorf, Staff
Xiaolei Shi, Graduate Student
Dan Yao, Research Associate