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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
College of Food, Agricultural, and Natural Resource Sciences
Department of Food Science and Nutrition

PI: Xiaoli Chen

Identifying Novel Functions of a New Adipokine in Insulin Resistance

The discovery of the endocrine role of adipose tissue and adipose tissue inflammation in the regulation of energy metabolism has significantly advanced our understanding of the mechanisms for the development of insulin resistance and type 2 diabetes. But how adipocyte dysfunction is linked to adipose tissue inflammation and systemic insulin resistance is far from understood. Insulin sensitivity is modulated by the complex mechanisms involving many adipokines and cytokines. These researchers have recently discovered a new adipokine. Based on their preliminary data, they are the first to discover that this adipokine appears to possess a pivotal function in insulin sensitization. Their central hypothesis is that adipose lipocalin 2 plays a role in mediating adipocyte dysfunction-induced systemic insulin resistance through the mechanism involving adipose inflammation and insulin resistance. The objective of this project is to discover the physiological significance of this new adipokine in the regulation of inflammation, insulin resistance, and glucose metabolism.

Group Members

David Brockman, Graduate Student
Hong Guo, Research Associate
Jennifer Hannaford, Graduate Student
Daozhong Jin, Research Associate
Yuanyuan Zhang, Graduate Student