Research Abstracts Online
January 2009 - March 2010
University of Minnesota Twin Cities
Department of Pediatrics
PI: K. Yeon Choi
Vaccine Protection Against Human Cytomegalovirus
Human cytomegalovirus (CMV) is one of the most common causes of birth defects and childhood disabilities and poses a significant risk for morbidity and mortality among immunocompromised individuals. Currently, there are no vaccines licensed for CMV. To develop a CMV vaccine that elicits a strong cell mediate response, T cell epitopes from viral proteins must be identified. Many major targets of cell mediate response have been identified but immunodominant epitopes have been not been mapped in guinea pig CMV. This model will characterize CMV antigen specific T cell epitopes and possible vaccine targets.