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January 2009 - March 2010

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University of Minnesota Twin Cities
Office of the Vice President for Research
Hormel Institute

PI: Zigang Dong

Computational Biology and Computer-aided Drug Discovery

These researchers are using Supercomputing Institute resources for multiple projects supporting their work concerning new treatments of cancer. The projects include: high-throughput docking of several small-molecule libraries in search of possible Thymidilate Synthase protein inhibitors; QM-docking of 6-Gingerol to the binding site of Leucotriene A4 Hydrolase and virtual screening in search of possible inhibitors; and a search for the structural basis for the inhibition of TOPK by a small-molecule compound

Group Member

Angelo Pugliese, Research Associate