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Research Abstracts Online
January 2009 - March 2010

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University of Minnesota Twin Cities
Medical School
Department of Medicine

PI: Arkadiusz Dudek

Mechanisms of Action of VG5Q Inhibition

Angiogenesis is a process involved in the formation of new vessels, and is essential for tumor growth and metastases. Angiogenic factors are critical for the initiation of angiogenesis and maintenance of the vascular network. VG5Q is a newly discovered protein that acts as a potent angiogenic factor in promoting angiogenesis and has also been implicated in the vascular pathophysiology of Klippel-Trenaunay syndrome. However, little is known about its role in cancer progression.

These researchers screened VG5Q expression from a number of cancer cell lines and endothelial cells. They have discovered that VG5Q silencing has profound effects on cancer cell biology, suggesting the hypothesis that the role of VG5Q may not be limited to angiogenic signaling in endothelial cells. The researchers plan to do further work to understand mechanism of action of this protein in cancer cells.

Group Member

Kaoru Terai, Staff